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viral envelope [ˌvaɪərəlˈenvələʊp] N

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These BSL 2 recombinants can be used for determination of neutralizing serum antibodies against pathogens of humans and animals which can only be handled under BSL3 or BSL 4 conditions.

Basis for the generation of these recombinants is a novel protein expression strategy which uses glycoprotein B of BoHV-1 as transporter to incorporate foreign proteins into the viral envelope.

Applicability of this approach was shown by construction of a recombinant which carries the HA1 subunit of HPAIV H5N1 ( Vietnam ) in the envelope of viral particles.

www.fli.bund.de

Sie sollen der Bestimmung von neutralisierenden Antikörpern gegen Pathogene von Mensch und Tier, die den Biosicherheitsstufen 3 oder 4 zugeordnet werden, dienen.

Basis dafür ist eine neuartige Expressionsstrategie, die das Glycoprotein B von BHV-1 verwendet, um fremde Proteine in der Virushülle zu verankern.

So wurde eine Rekombinante entwickelt, welche die HA1 Untereinheit von HPAIV H5N1 ( Vietnam ) in der Virushülle trägt.

www.fli.bund.de

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