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For example, the article on the vitamin deficiency disease beriberi speculates that it is caused by a fungus, vitamins not having been discovered at the time.
en.wikipedia.org
As early as 1755, pellagra was recognized by doctors as being a niacin deficiency disease.
en.wikipedia.org
Despite the presence of the "de novo" pathway, the salvage reactions are essential in humans; a lack of niacin in the diet causes the vitamin deficiency disease pellagra.
en.wikipedia.org

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